Each tablet contains Ciprofloxacin HCL, equivalent to 500 mg as the active ingredient.
It also contains maize starch, microcrystalline cellulose, crospovidone, sodium starch glycolate, povidone, magnesium stearate, and colloidal silicon dioxide as inactive ingredients.
Ciprofloxacin is a fluoroquinolone antibacterial highly active against gram-negative bacteria such as Shigella, Campylobacter, Neisseria, and Pseudomonas, as well as some gram-positive bacteria such as streptococcus pneumonia and Enterococcus faecalis. It is active against Chlamydia and some Mycobacteria.
Ciprofloxacin is also used in the treatment of a wide range of infections of the gastrointestinal system (including typhoid fever, parathyroid fever, traveler’s diarrhea, cholera, biliary tract infections) respiratory tract infections (including pseudomonal infections and anthrax not for pneumococcal pneumonia), infections of the urinary tract, gonorrhea, bone and joint infections, ear infections (otitis external and otitis media), meningococcal meningitis, and infections of the blood caused by sensitive organisms.
Dosage and Administration
Ciprofloxacin tablets should be taken according to the dose prescribed by a physician
- Respiratory – tract infections, 500 to 750mg, 12 hourly
- Urinary-tract infections 250 to 750mg 12 hourly
- Acute uncomplicated cystitis 250 mg 12 hourly for 3 days
- Acute or chronic prostatitis 500mg 12 hourly for 28 days
- Gonorrhea, 500mg as a single dose
- Surgical prophylaxis 750mg 60 minutes before the procedure
- Most other infections, 500mg 12 hourly (increased to 750mg 12 hourly in severe or deep-seated infection)
- Ciprofloxacin tablets are not generally recommended for children and adolescents but if considered essential, doses of 5 to 15 mg per kg 12 hourly by mouth or 4 to 8 mg per kg 12 hourly intravenously have been suggested
Ciprofloxacin acts by inhibiting the A subunit of DNA gyrase (topoisomerase)
Ciprofloxacin is rapidly and well absorbed from the gastrointestinal tract. Oral bioavailability is approximately 70% and peak plasma concentration of about 2.5μg per ml is achieved 1 to 2 hours after a dose of about 500mg by mouth. Absorption may be delayed by the presence of food but is not substantially affected overall. It is eliminated principally by urinary excretion, but non-renal clearance may account for about a third of elimination and includes hepatic metabolism, billary excretion, and possibly transluminal secretion across the intestinal mucosa
Ciprofloxacin tablet is contraindicated in patients who are hypersensitive to ciprofloxacin HCL or to any of the excipients
Warnings and Precautions
- Ciprofloxacin tablets should be used with caution in patients with epilepsy or a history of Central Nervous System Disorders
- Tendon damage may occur rarely with Ciprofloxacin and treatment should be discontinued if patients experience tendon pain, inflammation, or rupture
- Care is necessary for patients with impaired liver or kidney function, Glucose-6-phosphate Dehydrogenase deficiency, or Myasthenia Gravis
- An adequate fluid intake should be maintained during treatment with Ciprofloxacin
- The ability to drive or operate machinery may be impaired by Ciprofloxacin
Possible Side Effects
Gastrointestinal disturbances including nausea, vomiting, diarrhea, abdominal pain, and dyspepsia are the frequent adverse effects. Headache, dizziness, and restlessness are also common side effects. Some patients may have tremors, drowsiness, insomnia, nightmares, visual disturbances, and more rarely, hallucinations or psychotic reactions.
Symptoms and Treatment of
Seek immediate medical attention if a dose more than recommended is taken
Possible Interactions with Food or Drugs
Ciprofloxacin may interact with many analgesics, antacids, metal ions, anticoagulants, antiepileptics, antimigraine, drugs, antineoplastics and immunosuppressants, antivirals, anxiolytics, histamine H2-antagonists, probenecid, and xanthenes. Medicines containing aluminum, magnesium, iron or zinc may reduce the absorption of Ciprofloxacin. Taking NSAIDs with Ciprofloxacin may induce convulsions in patients. Dairy products with high calcium content (milk, yogurt, etc.) might also interfere with the absorption of some fluoroquinolones.
Pregnancy and Lactation
Ciprofloxacin and related fluoroquinolones have, like nalidixic acid, been shown to cause degenerative changes in weight-bearing joints of young animals. It has been suggested that these compounds should not be used in children, adolescents, pregnant women, or breast-feeding mothers
Yellow round film-coated tablets packed in PVC/Aluminum foil blister packs of 10 tablets by a blister
Ciprofloxacin Tablet 500 mg should be stored below 30 degrees Celsius and away from moisture and light. Keep out of reach of children.